Abstract
Phytochemical investigation of the leaves of Centella asiatica resulted in the isolation and characterization of eight triterpenes and/or saponins [which were characterized as 23-O-acetylmadecassoside (1), asiatic acid (2), madecassic acid (3), asiaticoside C (4), asiaticoside F (5), asiaticoside (6), madecassoside (7), and 23-O-acetylasiaticoside B (8)] together with sitosterol 3-O-β-glucoside (9), stigmasterol 3-O-β-glucoside (10), and querectin-3-O-β-D-glucuronide (11). A new ursane-derived saponin (23-O-acetylmadecassoside) and a new oleanane-derived saponin (23-O-acetylasiaticoside B) were found as well. Structure elucidation was done by using spectroscopic techniques (HR‐ESI‐MS, 1D and 2D NMR), chemical methods, and comparative literature studies.
Key words
Centella asiatica
- Apiaceae - saponins - 23‐O‐acetylmadecassoside - 23‐O‐acetylasiaticoside B
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Ph.D. Ikhlas A. Khan
School of Pharmacy
National Center for Natural Products Research
University of Mississippi
University, MS 38677
USA
Telefon: + 1 66 29 15 78 21
Fax: + 1 66 29 15 79 89
eMail: ikhan@olemiss.edu
