Abstract
Investigation of characteristic constituents of the roots of Glycyrrhiza uralensis Fischer led to isolation of four new triterpene glucuronides, namely uralsaponins C–F (1–4), an artificial product, namely the methyl ester of glycyrrhizin (5), as well as six known triterpene glucuronides (6–11). These new compounds were identified by 1D and 2D NMR spectroscopic analysis. The cytotoxicity of the selected compounds and their aglycones were evaluated against HeLa and MCF-7 cancer cell lines, and the preliminary structure-activity relationship was also elucidated.
Key words
Glycyrrhiza uralensis Fischer -
Glycyrrhiza
- Leguminosae - triterpene glucuronides - uralsaponins C–F - cytotoxic activities
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Prof. Ping Li
Key Laboratory of Modern Chinese Medicines
China Pharmaceutical University, Ministry of Education
24 Tongjia Lane
Nanjing 210009
China
Phone: + 86 25 83 27 13 79
Fax: + 86 25 83 27 13 79
Email: liping2004@126.com
