Aromatase and Sulfatase Inhibitors from Lepiota americana

Dong-Seon Kim; Hyeh-Jean Jeong; Krishna P. L. Bhat; So-Young Park; Soo-Hyon Kang; Eun-Hwa Yoo; Minna Lee; Hang-Woo Lee; Robert J. Krueger; Darrick S. H. L. Kim*

doi:10.1055/s-0029-1243115

Planta Med 2000; 66(1): 78-79
DOI: 10.1055/s-0029-1243115

Letter

Aromatase and Sulfatase Inhibitors from Lepiota americana

Dong-Seon Kim¹ ^, ² , Hyeh-Jean Jeong¹ ^, ² , Krishna P. L. Bhat¹ , So-Young Park¹ , Soo-Hyon Kang¹ , Eun-Hwa Yoo¹ , Minna Lee¹ , Hang-Woo Lee¹ , Robert J. Krueger³ , Darrick S. H. L. Kim¹ ^,*

¹Program for Collaborative Research in the Pharmaceutical Sciences (M/C 877) and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
²First two authors made an equal contribution
³School of Pharmacy, Ferris State University, Big Rapids, MI, U.S.A.

Abstract

From an edible mushroom Lepiota americana Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC_50 =5.7µM and 3β-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC_50 =0.9µM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfatase nor was 3β-hydroxy-5,8-epidioxyergosta- 6,22-diene active against aromatase.

Volltext

Referenzen

References

1 Kurashige S, Akuzawa Y, Endo F. Immunopharmacol Immunotoxicol 1997 19: 175-183
2 Kim D S, Baek N -I, Oh S R, Jung K Y, Lee I S, Kim J H, Lee H K. Arch Pharm Res 1997 20: 201-205
3 Kahlos K, Kangas L, Hiltunen R. Planta Medica 1989 55: 389-390
4 Engler M, Anke T, Sterner O. Z Naturforsch [C] 1998 53: 318-324
5 Lindequist U, Lesnau A, Teuscher E, Pilgrim H. Pharmazie 1989 44: 570-580
6 Santen R J, Manni A, Harvey H A. Endocr Rev 1990 11: 221-265
7 Pasqualini J R, Gelly C, Nguyen B L, Vella C. J Steroid Biochem (Proc.) 1989 34: 155-163
8 Yue W, Santen R. J Semin Oncol 1996 23 Suppl. 9: 21-27
9 Hawkins R A, Thomson M L, Killen E. Breast Cancer Res Treat 1985 6: 75-87
10 Harvey H A. J Semin Oncol 1996 23, Suppl 9: 33-38
11 Tilson-Mallett N, Santner S J, Feil P D, Santen R J. J Clin Endocrinol Metab 1983 57: 1125-1128
12 Sheikh Y M, Djerassi C. Tetrahedron 1974 30: 4095-4103
13 Kinjo J, Yokomizo K, Awata Y, Shibata M, Nohara T. Tetrahedron Lett 1987 28: 3697-3698
14 Schlunegger U P, Kuchen A, Clemencon H. Helv Chim Acta 1976 59: 1383-1388
15 Gerber N N. J Org Chem 1967 32: 4055-4057
16 Hoffman P G, Jones L A, Kuhn R W, Sitteri P K. Cancer (Phila.) 1980 46: 2801-2804
17 Thompson E A, Sitteri P K. J Biol Chem 1974 249: 5364-5372
18 Bradford M M. Anal Biochem 1976 27: 1643-1647
19 MacIndoe J H, Woods G, Jeffries L, Hinkhous M. Endocrinology 1988 23: 1281-1287
20 Gerber N N, Lechevalier M P. Biochemistry 1964 3: 598-602

Prof. Dr. Darrick S. H. L. Kim

Program for Collaborative Research in the Pharmaceutical Sciences (M/C 877) and Department of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

833 South Wood St.

Chicago, IL 60612

U.S.A.

eMail: dshlkim@uic.edu

Fax: +1(312)-413-5894

Telefon: +1(312)-996-1230