Antihyperglycemic Acetylenic Glucosides from Bidens pilosa

Abstract

In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C57BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyacetylenic glucosides, identified as 2-β-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne (1) and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne (2). A 3 : 2 mixture of compounds 1 and 2 effected a significant drop in blood glucose.

References

• 1 Zani C L, Chaves P PG, Queiroz R, De Oliveira A B, Cardoso J E, Anjos A MG, Grandi T SM. Phytomedicine 1995 2: 47-50
• 2 Winkelman M. Med Anthropol 1989 11: 255-268
• 3 Lin C C. Amer J Chin Med 1992 20: 269-279
• 4 Dimayuga R E, Agundez J. J Ethnopharmacol 1986 17: 183-193
• 5 Gonzalez A, Ferreira F, Vazquez A, Moyna P, Paz E A. J Ethnopharmacol 1993 39: 217-220
• 6 Zamora-Martinez M C, Pola C NP. J Ethnopharmacol 1992 35: 229-257
• 7 Boily Y, Van Puyvelde L. J Ethnopharmacol 1986 16: 1-13
• 8 Hoffmann B, Hölzl J. Phytochemistry 1988 27: 3700-3701
• 9 Ogawa K, Sashida Y. Phytochemistry 1992 31: 3657-3658
• 10 Sarg T M, Ateya A M, Farrag N M, Abbas F A. Acta Pharm Hung 1991 61: 317-323
• 11 Alvarez L, Marquina S, Virrareal M L, Alonso D, Aranda E, Delgado G. Planta Med 1996 62: 355-357
• 12 OubrØ A Y, Carlson T J, King S R, Reaven G M. Diabetologia 1997 40: 614-617
• 13 Rücker G, Kehrbaum S, Sakulas H, Lawong B, Goeltenboth F. Planta Med 1992 58: 266-269