RSS-Feed abonnieren
DOI: 10.1055/s-0029-1245168
© Georg Thieme Verlag KG Stuttgart · New York
Die Zukunft der invasiven Parkinson-Therapie
Parkinson’s Disease – the Future of Invasive TherapyPublikationsverlauf
Publikationsdatum:
01. März 2010 (online)

Zusammenfassung
Invasive Therapien haben in der Behandlung der Parkinson-Erkrankung eine lange Tradition. Während die tiefe Hirnstimulation bei fortgeschrittener Parkinson-Erkrankung mit Fluktuationen mittlerweile zu den etablierten Therapieverfahren zählt, sind für die Anwendung von Duodopa und Apomorphin noch Klasse I-Studien erforderlich. Die Transplantationen von fötalen Zellen und zukünftig vielleicht Stammzellen, und die Gentherapie gehören zu den zukünftig aussichtsreichen Interventionen.
Abstract
For the treatment of Parkinson’s disease invasive therapies have a long tradition. Deep brain stimulation is a well-established treatment option for the treatment of advanced Parkinson’s disease with fluctuations. Further promising interventions for invasive therapy of Parkinson’s disease are transplantation of foetal cells and stem cells, gene therapy and the use of duodopa and apomorhine.
Schlüsselwörter
invasive Therapien bei Parkinson - Transplantation - Gentherapie - tiefe Hirnstimulation
Keywords
invasive therapy by Parkinson’s disease - transplantation - gene therapy - deep brain stimulation
Literatur
- 1 Hassler R, Mundinger F, Riechert T. Stereotaxis in Parkinson Syndrome: Clinical-anatomical contributions to its physiology,
with an atlas of the basal ganglia in Parkinsonism. Berlin, Heidelberg, New York; Springer Verlag 1979
Reference Ris Wihthout Link
- 2
Lindvall O, Bjorklund A.
Cell therapy in Parkinson’s disease.
NeuroRx.
2004;
1
382-393
Reference Ris Wihthout Link
- 3
Bjorklund A.
Intracerebral transplantation: prospects for neuronal replacement in neurodegenerative
diseases.
Res Publ Assoc Res Nerv Ment Dis.
1993;
71
361-74
Reference Ris Wihthout Link
- 4
Lindvall O, Rehncrona S, Brundin P. et al .
Neural transplantation in Parkinson’s disease: the Swedish experience.
Prog Brain Res.
1990;
82
729-734
Reference Ris Wihthout Link
- 5
Freed C R, Greene P E, Breeze R E. et al .
Transplantation of embryonic dopamine neurons for severe Parkinson’s disease.
N Engl J Med.
2001;
344
710-719
Reference Ris Wihthout Link
- 6
Olanow C W, Goetz C G, Kordower J H. et al .
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson’s
disease.
Ann Neurol.
2003;
54
403-414
Reference Ris Wihthout Link
- 7
Kordower J H, Chu Y, Hauser R A. et al .
Transplanted dopaminergic neurons develop PD pathologic changes: a second case report.
Mov Disord.
2008;
23
2303-2306
Reference Ris Wihthout Link
- 8
Kordower J H, Chu Y, Hauser R A. et al .
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson’s
disease.
Nat Med.
2008;
14
504-506
Reference Ris Wihthout Link
- 9
Marks W J, Ostrem J L, Verhagen L. et al .
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus
serotype 2-neurturin) to patients with idiopathic Parkinson’s disease: an open-label,
phase I trial.
Lancet Neurol.
2008;
7
400-408
Reference Ris Wihthout Link
- 10
Eberling J L, Jagust W J, Christine C W. et al .
Results from a phase I safety trial of hAADC gene therapy for Parkinson disease.
Neurology.
2008;
70
1980-1983
Reference Ris Wihthout Link
- 11
Kaplitt M G, Feigin A, Tang C. et al .
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne
GAD gene for Parkinson’s disease: an open label, phase I trial.
Lancet.
2007;
369
2097-2105
Reference Ris Wihthout Link
- 12
Castaigne P, Laplane D, Dordain G.
Clinical experimentation with apomorphine in Parkinson’s disease.
Res Commun Chem Pathol Pharmacol.
1971;
2
154-158
Reference Ris Wihthout Link
- 13
Stibe C M, Kempster P A, Lees A J. et al .
Subcutaneous apomorphine in parkinsonian on-off oscillations.
Lancet.
1988;
331
403-406
Reference Ris Wihthout Link
- 14
Poewe W, Kleedorfer B, Gerstenbrand F. et al .
Subcutaneous apomorphine in Parkinson’s disease.
Lancet.
1988;
1
943
Reference Ris Wihthout Link
- 15
Wenning G K, Bösch S, Luginger E. et al .
Effects of long-term, continuous subcutaneous apomorphine infusions on motor complications
in advanced Parkinson’s disease.
Adv Neurol.
1999;
80
545-548
Reference Ris Wihthout Link
- 16
Gunzler S A, Koudelka C, Carlson N E. et al .
Effect of low concentrations of apomorphine on parkinsonism in a randomized, placebo-controlled,
crossover study.
Arch Neurol.
2008;
65
193-198
Reference Ris Wihthout Link
- 17
Dewey R B, Hutton J T, LeWitt P A. et al .
A randomized, double-blind, placebo-controlled trial of subcutaneously injected apomorphine
for parkinsonian off-state events.
Arch Neurol.
2001;
58
1385-1392
Reference Ris Wihthout Link
- 18
Antonini A, Isaias I U, Canesi M. et al .
Duodenal levodopa infusion for advanced Parkinson’s disease: 12-month treatment outcome.
Mov Disord.
2007;
22
1145-1149
Reference Ris Wihthout Link
- 19
Nutt J G, Jansson R, Willows T. et al .
Long-term 24-hour duodenal infusion of levodopa: outcome and dose requirements.
Neurology.
2005;
65
1506-1507
Reference Ris Wihthout Link
- 20
Nyholm D, Nilsson Remahl A IM, Dizdar N. et al .
Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson
disease.
Neurology.
2005;
64
216-23
Reference Ris Wihthout Link
- 21
Weaver F M, Follett K, Stern M. et al .
Bilateral deep brain stimulation vs. best medical therapy for patients with advanced
Parkinson disease: a randomized controlled trial.
Jama.
2009;
301
63-73
Reference Ris Wihthout Link
- 22
Deuschl G, Schade-Brittinger C, Krack P. et al .
A randomized trial of deep-brain stimulation for Parkinson’s disease.
N Engl J Med.
2006;
355
896-908
Reference Ris Wihthout Link
- 23
Deep-Brain Stimulation for Parkinson’s Disease Study Group .
Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus
pallidus in Parkinson’s disease.
N Engl J Med.
2001;
345
956-963
Reference Ris Wihthout Link
- 24
Rodriguez-Oroz M C, Obeso J A, Lang A E. et al .
Bilateral deep brain stimulation in Parkinson’s disease: a multicentre study with
4 years follow-up.
Brain.
2005;
128
2240-2249
Reference Ris Wihthout Link
- 25
Okun M S, Fernandez H H, Wu S S. et al .
Cognition and mood in Parkinson’s disease in subthalamic nucleus versus globus pallidus
interna deep brain stimulation: the COMPARE trial.
Ann Neurol.
2009;
65
586-595
Reference Ris Wihthout Link
- 26
Coban A, Hanagasi H A, Karamursel S. et al .
Comparison of unilateral pallidotomy and subthalamotomy findings in advanced idiopathic
Parkinson’s disease.
Br J Neurosurg.
2009;
23
23-29
Reference Ris Wihthout Link
- 27
Volkmann J, Allert N, Voges J. et al .
Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD.
Neurology.
2001;
56
548-551
Reference Ris Wihthout Link
- 28
Stefani A, Lozano A M, Peppe A. et al .
Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in
severe Parkinson’s disease.
Brain.
2007;
130
1596-1607
Reference Ris Wihthout Link
- 29
Hamani C, Stone S, Laxton A. et al .
The pedunculopontine nucleus and movement disorders: anatomy and the role for deep
brain stimulation.
Parkinsonism Relat Disord.
2007;
13 (Suppl 3)
S276-S280
Reference Ris Wihthout Link
- 30
Smith Y, Raju D, Nanda B. et al .
The thalamostriatal systems: anatomical and functional organization in normal and
parkinsonian states.
Brain Res Bull.
2009;
78
60-68
Reference Ris Wihthout Link
- 31
Plaha P, Gill S S.
Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson’s disease.
Neuroreport.
2005;
16
1883-1887
Reference Ris Wihthout Link
- 32
Alvarez L, Macias R, Pavón N. et al .
Therapeutic efficacy of unilateral subthalamotomy in Parkinson’s disease: results
in 89 patients followed for up to 36 months.
J Neurol Neurosurg Psychiatry.
2009;
80
979-985
Reference Ris Wihthout Link
- 33
Merello M, Tenca E, Pérez Lloret S. et al .
Prospective randomized 1-year follow-up comparison of bilateral subthalamotomy versus
bilateral subthalamic stimulation and the combination of both in Parkinson’s disease
patients: a pilot study.
Br J Neurosurg.
2008;
22
415-422
Reference Ris Wihthout Link
- 34
Tass P A, Silchenko A N, Hauptmann C. et al .
Long-lasting desynchronization in rat hippocampal slice induced by coordinated reset
stimulation.
Phys Rev E Stat Nonlin Soft Matter Phys.
2009;
80
011 902
Reference Ris Wihthout Link
- 35
Hauptmann C, Tass P A.
Cumulative and after-effects of short and weak coordinated reset stimulation: a modeling
study.
J Neural Eng.
2009;
6
016 004
Reference Ris Wihthout Link
- 36
Hauptmann C, Popovych O, Tass P A.
Desynchronizing the abnormally synchronized neural activity in the subthalamic nucleus:
a modeling study.
Expert Rev Med Devices.
2007;
4
633-650
Reference Ris Wihthout Link
Prof. Dr. Günther Deuschl
Neurologische Klinik, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Christian-Albrechts-Universität
zu Kiel
Schittenhelmstr. 10
24105 Kiel
eMail: g.deuschl@neurologie.uni-kiel.de