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Rofo 2011; 183(1): 12-23
DOI: 10.1055/s-0029-1245880
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Chemoperfusion und -embolisation von Lebermetastasen

Chemoperfusion and Embolization in the Treatment of Liver MetastasesT. J. Vogl1 , M. G. Mack1 , K. Eichler1 , S. Zangos1 , N. N. Naguib1 , T. Gruber-Rouh1
  • 1Institut für Diagnostische und Interventionelle Radiologie, J.-W.-Goethe-Universität Frankfurt
Further Information

Publication History

eingereicht: 12.5.2010

angenommen: 20.10.2010

Publication Date:
26 November 2010 (online)

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Zusammenfassung

Vorstellung der Techniken und Indikationsstellungen der regionalen Chemotherapieverfahren in der Behandlung von irresektablen Lebermetastasen verschiedener Primärtumoren im Rahmen des interdisziplinären Therapiemanagements. Zu diesen transarteriellen Therapieverfahren gehören die hepatische arterielle Infusion (HAI) sowie transarterielle Chemoembolisation (TACE), Chemoembolisation mit Zytostatika beladenen Mikrosphären (DEBs), transarterielle Embolisation (TAE) und selektive interne Radiotherapie (SIRT). Regionale Chemotherapieverfahren in der Behandlung der Lebermetastasen stellen eine minimalinvasive Therapieoption dar, die erfolgreich mit chirurgischer Resektion und/oder lokal ablativen Verfahren wie Radiofrequenzablation (RFA), laserinduzierte Thermotherapie (LITT), Mikrowellenablation (MWA) kombiniert werden kann. Diese Verfahren erlauben eine Optimierung lokaler Kontrollrate bei strikt intrahepatischen Prozessen und führen zum Erhöhen der Überlebensraten bei möglichst höherer Lebensqualität.

Abstract

Presentation of techniques and procedures for regional chemotherapy in the treatment of unresectable liver metastases from different primary tumors as a modality of interdisciplinary therapy management. Such transarterial therapy methods include hepatic arterial infusion (HAI), transarterial chemoembolization (TACE), chemoembolization with cytostatic-loaded microspheres (DEBs), transarterial embolization (TAE) and selective internal radiation therapy (SIRT). Regional chemotherapy procedures in the treatment of liver metastases represent a minimally invasive treatment option that can be successfully combined with surgical resection and/or radiofrequency (RFA), laser-induced thermotherapy (LITT), microwave ablation (MWA). These procedures allow optimization of the local control rate with strictly intrahepatic processes and lead to increased survival rates without any quality of life restriction.

Key words

regional chemotherapies - liver metastases - MRI

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Prof. Thomas J. Vogl

Institut für Diagnostische und Interventionelle Radiologie, J.-W.-Goethe-Universität Frankfurt

Theodor-Stern Kai 7

60596 Frankfurt

Phone: ++ 49/69/63 01 72 77

Fax: ++ 49/69/63 01 72 58

Email: T.vogl@em.uni-frankfurt.de