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TumorDiagnostik & Therapie 2011; 32(1): 48-53
DOI: 10.1055/s-0029-1246043
Thieme Onkologie aktuell

© Georg Thieme Verlag KG Stuttgart · New York

Aktuelle molekular-zytogenetische Aspekte zur Pathologie und Differenzierung von extranodalen Marginalzonen B-Zell-Lymphomen vom MALT-Typ und gastrointestinalen diffusen großzelligen B-Zell-Lymphomen

Current Aspects of the Pathology and Differentiation of Extranodal Marginal Zone B-Cell Lymphoma, MALT-Type, and Gastrointestinal Diffuse Large B-Cell LymphomaL. Floßbach1 , H. A. Kestler2 , 3 , T. M. Gress3 , 4 , P. Möller1 , T. F. E. Barth1
  • 1Institut für Pathologie, Universitätsklinikum Ulm
  • 2Institut für Neuroinformatik, Universität Ulm
  • 3Klinik für Innere Medizin I, Universitätsklinikum Ulm
  • 4Klinik für Gastroenterologie, Endokrinologie und Stoffwechsel, Philipps Universität Marburg
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Publication History

eingereicht: 23.12.2009

angenommen: 19.4.2010

Publication Date:
01 February 2011 (online)

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Zusammenfassung

Das Marginalzonen B-Zell-Lymphom vom MALT-Typ (MZBL, MT) ist ein häufig im Magen lokalisiertes, niedrig malignes B-Zell-Lymphom mit typischer Morphologie und Zytogenetik. Daneben existieren das gastrointestinale diffuse großzellige B-Zell-Lymphom (DLBCL) und Kompositlymphome (ComL) mit koexistenter groß- und kleinzelliger Zytologie, die aufgrund dessen ein faszinierendes Modell hinsichtlich der Lymphomprogression darstellen. Im vorliegenden Review werden die wichtigsten aktuellen Aspekte zur molekularen Charakterisierung der MZBL, MT und der gastrointestinalen DLBCL sowie einer Relation dieser Lymphomentitäten untereinander zusammengefasst, die sie klar von den nodalen DLBCL abgrenzen.

Abstract

The marginal zone B-cell lymphoma, MALT-type (MZBL, MT) is a low-grade B-cell lymphoma which is predominantly localised in the stomach with a typical morphology and cytogenetic pattern. The coexistence of a diffuse large B-cell lymphoma (DLBCL) with an MZBL, MT in the gastrointestinal tract is defined as a composite lymphoma (ComL) and represents a fascinating model of lymphoma progression. In this review we focus on current aspects regarding the molecular characterisation of MZBL, MT and gastrointestinal DLBCL and their mutual relationships.

Schlüsselwörter

MALT-Lymphom - gastrales DLBCL - Molekularbiologie

Key words

MALT lymphom - gastric DLBCL - molecular biology

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Lucia Floßbach

Institut für Pathologie, Universitätsklinikum Ulm

Albert-Einstein-Allee 11

89081 Ulm

Email: lucia.flossbach@uni-ulm.de