Cranial Chondrosarcoma and Recurrence

Orin G Bloch; Brian J Jian; Isaac Yang; Seunggu J Han; Derick Aranda; Brian J Ahn; Andrew T Parsa

doi:10.1055/s-0029-1246218

Skull Base, Table of Contents

Skull Base 2010; 20(3): 149-156
DOI: 10.1055/s-0029-1246218

ORIGINAL ARTICLE

Cranial Chondrosarcoma and Recurrence

Orin G. Bloch¹ , Brian J. Jian¹ , Isaac Yang¹ , Seunggu J. Han¹ , Derick Aranda¹ , Brian J. Ahn¹ , Andrew T. Parsa¹

¹Department of Neurological Surgery, University of California at San Francisco, San Francisco, California

Abstract

ABSTRACT

The literature regarding recurrences in patients with cranial chondrosarcoma is limited to small series performed at single institutions, raising the question if these data precisely reflect the true recurrence of this tumor for guiding the clinician in the management of these patients. An extensive systematic review of the English literature was performed. The patients were stratified according to treatment modality, treatment history, histological subtype, and histological grade, and the recurrence rates were analyzed. A total of 560 patients treated for cranial chondrosarcoma were included. Five-year recurrence rate among all patients was 22% with median follow-up of 60 months and median disease-free interval of 16 months. Tumor recurrence was more common in patients who only received surgery or had mesenchymal subtype tumors. Our systematic review closely reflects the actuarial recurrence rate and provides predictive factors in the recurrence of cranial chondrosarcoma.

KEYWORDS

Cranial chondrosarcoma - recurrence - systematic review

Full Text

References

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Andrew T ParsaM.D. Ph.D.

Department of Neurosurgery

University of California at San Francisco, San Francisco, CA 94143

Email: parsaa@neurosurg.ucsf.edu