Planta Med 2010; 76(15): 1762-1764
DOI: 10.1055/s-0030-1249814
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Alkaloids from Roots of Stephania rotunda and Their Cholinesterase Inhibitory Activity

Tran Manh Hung1 , Nguyen Hai Dang2 , Jin Cheol Kim3 , Han-Su Jang4 , Sung-Woo Ryoo5 , Jeong Hyung Lee5 , Jae Sue Choi6 , KiHwan Bae7 , Byung Sun Min1
  • 1College of Pharmacy, Catholic University of Daegu, Gyeongbuk, Korea
  • 2Institute of Natural Product Chemistry, Vietnamese Academy of Science and Technology, Hanoi, Vietnam
  • 3Korea Research Institute of Chemical Technology, Daejeon, Korea
  • 4Gyeongbuk Institute for Bio Industry, Gyeongbuk, Korea
  • 5College of Natural Sciences, Kangwon National University, Kangwon, Korea
  • 6Faculty of Food Science and Biotechnolgy, Pukyoung National University, Busan, Korea
  • 7College of Pharmacy, Chungnam National University, Daejeon, Korea
Further Information

Publication History

received July 13, 2009 revised March 8, 2010

accepted March 15, 2010

Publication Date:
13 April 2010 (online)

Abstract

In the course of screening plants used in folk medicine as memory enhancers, a 70 % ethanolic extract of Stephania rotunda roots showed significant AChE inhibitory activity. Repeated column chromatography led to the isolation of a new protoberberine alkaloid, which we named stepharotudine (1), and seven known compounds (28). The chemical structures of the isolated compounds were elucidated based on extensive 1D and 2D NMR spectroscopic data. Compounds 18 were investigated in vitro for their anticholinesterase activity using a rat cortex AChE enzyme.

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Prof. Byung Sun Min

College of Pharmacy
Catholic University of Daegu

330 Geumnak 1-ri

Gyeongbuk 712–702

Korea

Phone: + 82 5 38 50 36 13

Fax: + 82 5 38 50 36 02

Email: bsmin@cu.ac.kr