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DOI: 10.1055/s-0030-1250057
© Georg Thieme Verlag KG Stuttgart · New York
Two New Drimane Sesquiterpenes, Fudecadiones A and B, from the Soil Fungus Penicillium sp. BCC 17468
Publication History
received February 17, 2010
revised May 24, 2010
accepted May 26, 2010
Publication Date:
24 June 2010 (online)

Abstract
Two new drimane sesquiterpenoids, fudecadione A and fudecadione B (1, 2), together with the known brefeldin A (3) and fulvic acid (4), were isolated from the soil fungus Penicillium sp. BCC 17468. Chemical structures were determined based on spectroscopic evidence including 1D and 2D NMR and mass spectral data. The proposed relative stereochemistry of fudecadiones A and B was based upon NOESY spectral data and chemical means. Compounds 1 and 4 exhibited anticancer activity against MCF-7, KB, and NCI-H187, with IC50 values in the range of 5.05–45.43 µg/mL, while compound 2 was inactive against these tumor cells. Brefeldin (3) also displayed antimalarial activity against Plasmodium falciparum (K1, multidrug-resistant strain), with an IC50 value of 1.12 µg/mL.
Key words
drimane sesquiterpenes - antimalaria - Penicillium sp. - Trichocomaceae
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Pattama Pittayakhajonwut
National Center for Genetic Engineering and Biotechnology
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