Endoscopy 2011; 43(8): 727-730
DOI: 10.1055/s-0030-1256338
Case report/series

© Georg Thieme Verlag KG Stuttgart · New York

Defining the endoscopic appearances of tylosis using conventional and narrow-band imaging: a case series

H.  Smart1 , R.  Kia1 , S.  Subramanian1 , S.  Khalid1 , F.  Campbell2 , A.  Ellis1
  • 1Department of Gastroenterology, Royal Liverpool University Hospital, Liverpool, United Kingdom
  • 2Department of Pathology, Royal Liverpool University Hospital, Liverpool, United Kingdom
Further Information

Publication History

submitted 4 December 2010

accepted after revision 3 January 2011

Publication Date:
27 May 2011 (online)

Tylosis is an autosomal dominant skin disorder strongly associated with esophageal squamous cell cancer. We present a single-operator experience of utilizing conventional endoscopy and narrow-band imaging with magnification to characterize esophageal appearances in tylosis. Nineteen consecutive patients with tylosis attending for surveillance endoscopy were studied. White-light imaging (WLI) and narrow-band imaging (NBI) were undertaken, with magnification being performed as necessary. On WLI, we classified 12 patients as having mild change, 5 moderate change, and 2 severe change. WLI can define changes to the esophageal mucosa of variable hyperkeratosis and identify more significant focal abnormalities. NBI enhances these mucosal changes, and NBI with magnification can demonstrate intrapapillary capillary loop changes compatible with dysplasia, prompting consideration of surgery. This report is the first to characterize the endoscopic appearances in tylosis.

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Dr. H. Smart

Department of Gastroenterology
Royal Liverpool University Hospital

Prescot Street
Liverpool
L7 8XP
United Kingdom

Fax: +44-151-7065832

Email: howard.smart@rlbuht.nhs.uk