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DOI: 10.1055/s-0030-1256338
© Georg Thieme Verlag KG Stuttgart · New York
Defining the endoscopic appearances of tylosis using conventional and narrow-band imaging: a case series
Publication History
submitted 4 December 2010
accepted after revision 3 January 2011
Publication Date:
27 May 2011 (online)
![](https://www.thieme-connect.de/media/endoscopy/201108/lookinside/thumbnails/10.1055-s-0030-1256338-1.jpg)
Tylosis is an autosomal dominant skin disorder strongly associated with esophageal squamous cell cancer. We present a single-operator experience of utilizing conventional endoscopy and narrow-band imaging with magnification to characterize esophageal appearances in tylosis. Nineteen consecutive patients with tylosis attending for surveillance endoscopy were studied. White-light imaging (WLI) and narrow-band imaging (NBI) were undertaken, with magnification being performed as necessary. On WLI, we classified 12 patients as having mild change, 5 moderate change, and 2 severe change. WLI can define changes to the esophageal mucosa of variable hyperkeratosis and identify more significant focal abnormalities. NBI enhances these mucosal changes, and NBI with magnification can demonstrate intrapapillary capillary loop changes compatible with dysplasia, prompting consideration of surgery. This report is the first to characterize the endoscopic appearances in tylosis.
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Dr. H. Smart
Department of Gastroenterology
Royal Liverpool University Hospital
Prescot Street
Liverpool
L7 8XP
United Kingdom
Fax: +44-151-7065832
Email: howard.smart@rlbuht.nhs.uk