An Improved Method for the Synthesis
of Carbazolones by Palladium/Copper-Catalyzed
Intramolecular Annulation of N-Arylenaminones

Bojie Weng; Rui Liu; Jing-Hua Li

doi:10.1055/s-0030-1258141

PAPER

An Improved Method for the Synthesis of Carbazolones by Palladium/Copper-Catalyzed Intramolecular Annulation of N-Arylenaminones

Bojie Weng, Rui Liu, Jing-Hua Li*
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
e-Mail: lijh@zjut.edu.cn;

Abstract

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Abstract

An improved method for the synthesis of carbazolones via the condensation of arylamines with 1,3-cyclodiketones followed by intramolecular oxidative cyclization catalyzed by palladium acetate and copper acetate in ethanol under an oxygen atmosphere was established. The improved method has the advantage of easily available starting materials and affords good yields.

Key words

carbazolones - intramolecular oxidative cyclization - oxygen - palladium acetate - copper acetate

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