Synthesis of New [2,3′:6′,3′′]Terpyridines
Using Iterative Cross-Coupling Reactions

Grégory Burzicki; Anne Sophie Voisin-Chiret; Jana Sopková-de Oliveira Santos; Sylvain Rault

doi:10.1055/s-0030-1258147

PAPER

Synthesis of New [2,3′:6′,3′′]Terpyridines Using Iterative Cross-Coupling Reactions

Grégory Burzicki, Anne Sophie Voisin-Chiret, Jana Sopková-de Oliveira Santos, Sylvain Rault*
Université de Caen Basse-Normandie, U.F.R. des Sciences Pharmaceutiques, Centre d’Etudes et de Recherche sur le Médicament de Normandie, UPRES EA-4258, FR CNRS INC3M, Boulevard Becquerel, 14032 Caen Cedex, France
Fax: +33(2)31566803; e-Mail: sylvain.rault@unicaen.fr;

Abstract

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Abstract

An efficient, regioselective, and global route to prepare terpyridines is described. A predictable strategy was developed, which is based on iterative cross-coupling reactions between bifunctional pyridylboronic acids as promising platforms and halobipyridines as key intermediates.

Key words

boron - cross-coupling - palladium - pyridines - regioselectivity

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References

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Compound VII is commercially available, but its synthesis is unknown in the literature.

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