Furan Ring Opening-Pyrrole
Ring Closure: Simple Route to 5-Alkyl-2-(aminomethyl)pyrroles

Alexander V. Butin; Tatyana A. Nevolina; Vitaly A. Shcherbinin; Maxim G. Uchuskin; Olga V. Serdyuk; Igor V. Trushkov

doi:10.1055/s-0030-1258165

PAPER

Furan Ring Opening-Pyrrole Ring Closure: Simple Route to 5-Alkyl-2-(aminomethyl)pyrroles

Alexander V. Butin*^a, Tatyana A. Nevolina^a, Vitaly A. Shcherbinin^a, Maxim G. Uchuskin^a, Olga V. Serdyuk^b, Igor V. Trushkov^c,d
^a Research Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University, Moskovskaya st. 2, Krasnodar 350072, Russian Federation
^b Department of Chemistry, Southern Federal University, Zorge 7, Rostov-on-Don, 344090, Russian Federation
^c Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russian Federation
^d Laboratory of Chemical Synthesis, Federal Research Center of Pediatric Hematology, Oncology, and Immunology, Leninskii av. 117/2, Moscow 105062, Russian Federation
Fax: +7(861)2596592.; e-Mail: alexander_butin@mail.ru; e-Mail: av_butin@yahoo.com;

Abstract

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Abstract

A simple route to 5-alkyl-2-(aminomethyl)pyrroles is proposed that is based on hydrolytic ring opening of 5-alkylfurfurylamines followed by pyrrole ring closure under Paal-Knorr conditions.

Key words

furans - ring opening - ring closure - pyrroles - polycycles

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References

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