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Synthesis 2010(16): 2705-2707
DOI: 10.1055/s-0030-1258173
DOI: 10.1055/s-0030-1258173
SHORTPAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Simple and Efficient Asymmetric Synthesis of Anxiolytic Drug Enciprazine
Further Information
Received
23 March 2010
Publication Date:
12 July 2010 (online)
Publication History
Publication Date:
12 July 2010 (online)
Abstract
A straightforward and efficient asymmetric synthesis of (S)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenoxy)propan-2-ol is described. The key intermediate, (S)-2-[(3,4,5-trimethoxyphenoxy)methyl]oxirane, was obtained by a hydrolytic kinetic resolution method using the catalyst (R,R)-salen-cobalt(III) complex.
Key words
trimethoxyphenol - resolution - chiral epoxide - methoxybenzenamine
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