Symmetrical 1,3-diynes were obtained in quantitative yields using
the copper(II) acetate catalyzed homocoupling of terminal alkynes
in the presence of a stoichiometric amount of piperidine at 25 ˚C
under aerobic conditions. We also accomplished facile syntheses
of unsymmetric 1,3-diynes by heterocoupling terminal alkynes in
very good yields under the reported reaction conditions.
terminal alkynes - copper(II) acetate - piperidine - homocoupling - heterocoupling - symmetric 1,3-diynes - unsymmetric 1,3-diynes
