Synthesis of Tetrahydroisoquinolines
via Cascade Reductive Amination of Isochromenylium Tetrafluoroborate
with Primary Amines

Hong-Ze Liao; Zhi-Long Hu; Kai Cui; Jiao Jiao; Yong Qin; Zhu-Jun Yao

doi:10.1055/s-0030-1258204

PAPER

Synthesis of Tetrahydroisoquinolines via Cascade Reductive Amination of Isochromenylium Tetrafluoroborate with Primary Amines

Hong-Ze Liao^a, Zhi-Long Hu^b, Kai Cui^b, Jiao Jiao^b, Yong Qin^a, Zhu-Jun Yao*^b
^a Department of Chemistry of Medicinal Natural Products and Key Laboratory of Drug Targeting, West China School of Pharmacy, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, P. R. of China
^b State Key Laboratory of Bioorganic and Natural Products Chemistry and e-Institute of Chemical Biology of Shanghai Universities, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai 200032, P. R. of China
e-Mail: yaoz@sioc.ac.cn;

Abstract

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Abstract

Reactions of isochromenylium tetrafluoroborates with various primary amines have been investigated under reductive amination conditions. The established cascade methodology provides a convenient one-step synthesis of various tetrahydroisoquinoline derivatives under mild conditions.

Key words

isochromenylium - reductive amination - tetrahydroisoquinoline - heterocycle - cascade reaction

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References

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