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DOI: 10.1055/s-0030-1258228
Recent Advances in the Synthesis of Carbohydrate Mimetics
Publication History
Publication Date:
25 August 2010 (online)
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Abstract
Highly diverse strategies are employed to mimic carbohydrates. Two subgroups of carbohydrate mimetics are very important: alterations of the core structure and modifications of the O-glycosidic linkage. This review presents methods, most of them developed in the 21st century, to mimic carbohydrates with a focus on their synthesis. A wide range of different reactions are discussed in order to access carbohydrate-like structures.
1 Introduction
1.1 Scope of the Review
2 Core Modifications
2.1 Modifications of Functional Groups
2.1.1 Additional Alkyl Substituents
2.1.2 Fluorine Substituents
2.2 Seven-Membered Rings
3 Linkage Modifications
3.1 N-Glycosides
3.2 S-Glycosides
3.3 C-Glycosides
3.4 Peptoidic Bonds
4 Miscellaneous
5 Conclusion and Outlook
Key words
carbohydrates - oligosaccharides - carbohydrate mimetics - C-glycosides - S-glycosides - N-glycosides
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