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Synthesis 2010(22): 3835-3838  
DOI: 10.1055/s-0030-1258264
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Facile and Efficient Synthesis of 4-Alkyl Derivatives of 3-Carbamoyl- and 3,5-Dicarbamoylpyridines as Nicotinamide Mimetics

Barbara Di Rienzo, Paolo Mellini, Silvano Tortorella, Daniela De Vita, Luigi Scipione*
Department of ‘Chimica e Tecnologie del Farmaco’, Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy
Fax: +39(06)49913133; e-Mail: luigi.scipione@uniroma1.it;
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Publication History

Received 16 July 2010
Publication Date:
22 September 2010 (online)

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Abstract

Nicotinamide plays a key role in many biological processes and, as a consequence, its derivatives could be attractive for the synthesis of biologically active compounds. Here a rapid and efficient­ way of preparing alkyl derivatives of nicotinamide, precisely, 4-alkyl-3-carbamoylpyridine and 4-alkyl-3,5-dicarbamoylpyridine is reported. The synthetic route developed adopts mild reaction conditions and produces target compounds in higher yields compared with methods described in literature.

Key words

amides - drugs - hydrogenation - nicotinamide derivatives - nitrile hydrolysis - pyridines