Abstract
The reaction of 5-amino-1H -imidazoles
with 3-methoxalylchromone provided a set of imidazo[4,5-b ]pyridines (1-desazapurines)
bearing the CO2 Me substituent at the α-position
of the pyridine core. The corresponding acids were synthesized by
subsequent hydrolysis of the ester function. Being typical purine
isosteres, 1-desazapurines are considered to be potent
pharmacophores, and are widely used in drug design and medicinal
chemistry.
Key words
3-methoxalylchromone - 5-aminoimidazoles - imidazo[4,5-b ]pyridines - 1-desazapurines - cyclocondensations
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21 Crystallographic data (excluding structure
factors) for the structures of 7a and 9b , reported in this paper, have been deposited
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1EZ, UK; Fax: +44 (1223)336033; E-mail: deposit@ccdc.cam.ac.uk,
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