Synthesis of Chromeno[3,4-b]quinolines: Electrophilic Aromatic Substitution under Heck Conditions

Abstract

The palladium-mediated intramolecular coupling reaction of 2-[(3-substituted-phenoxy)methyl]quinolines for preparing chromeno[3,4-b]quinolines was explored. The results of the cyclizations gave convincing evidence for an electrophilic aromatic substitution mechanism under standard Heck conditions.

palladium catalysis - Heck reaction - electrophilic aromatic substitution - chromenoquinoline - aryl-heteroaryl coupling

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