A Novel Approach to 1-Monosubstituted
1,2,3-Triazoles by a Click Cycloaddition/Decarboxylation
Process

Mei Xu; Chunxiang Kuang; Zhuo Wang; Qing Yang; Yubo Jiang

doi:10.1055/s-0030-1258357

PAPER

A Novel Approach to 1-Monosubstituted 1,2,3-Triazoles by a Click Cycloaddition/Decarboxylation Process

Mei Xu^a, Chunxiang Kuang*^a, Zhuo Wang^a, Qing Yang^b, Yubo Jiang^a
^a Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China
Fax: +86(21)65983191; e-Mail: kuangcx@tongji.edu.cn;
^b Department of Biochemistry, School of Life Sciences, Fudan University, Handan Road 220, Shanghai 200433, P. R. of China

Abstract

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Abstract

The synthesis of 1-monosubstituted 1,2,3-triazoles was achieved using azides and propiolic acid by copper-catalyzed click cycloaddition/decarboxylation, which was easily carried out in N,N-dimethylformamide at room temperature or 60 ˚C with yields ranging from moderate to excellent. The reaction conditions were found to be successful for aryl and vinyl azide reactants, including analogues with various functionalities.

Key words

click chemistry - copper catalysis - decarboxylation - heterocycle - 1-monosubstituted 1,2,3-triazole

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