Abstract
The first synthesis of 3-(dichloroacetyl)chromone from 3-(dimethylamino)-1-(2-hydroxyphenyl)propen-1-one
and dichloroacetyl chloride is described. The reaction of electron-rich
aminoheterocycles with 3-(dichloroacetyl)chromone provides a set
of diverse fused pyridines bearing the CHCl2 -substituent
at the α-position of the pyridine core. Subsequent hydrolysis
leads to the formation of annulated α-(formyl)pyridines.
Key words
3-(dichloroacetyl)chromone - 4H -1-benzopyran-4-one - heterocyclic amines - fused pyridines - annulation
reactions
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