The reaction of triiodoisocyanuric acid (TICA) with deactivated
arenes in acidic medium led to the efficient and regioselective
formation of the corresponding iodoarenes, in 55-88% isolated
yield. The acidity of the medium was found to be the most important
factor influencing the electrophilic iodination of weakly nucleophilic
substrates by TICA.
triiodoisocyanuric acid - iodination - deactivated
aromatic compound - iodoarene - electrophilic halogenation