Synthesis of New Dihydropyrimido[4,5-b]quinolinetrione Derivatives
Using a Four-Component Coupling Reaction

A. Khalafi-Nezhad; F. Panahi

doi:10.1055/s-0030-1258446

PAPER

Synthesis of New Dihydropyrimido[4,5-b]quinolinetrione Derivatives Using a Four-Component Coupling Reaction

A. Khalafi-Nezhad*, F. Panahi*
Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
Fax: +98(711)2280926; e-Mail: khalafi@chem.susc.ac.ir;

Abstract

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Abstract

A convenient and one-pot method for the efficient synthesis of the novel 8,9-dihydro-8,8-dimethyl-5,10-diphenylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-trione derivatives via a four-component condensation reaction of aldehydes, amines, dimedone, and barbituric acid in the presence of tungestophosphoric acid (H₃PW₁₂O₄₀) as catalyst is described. This new approach proceeded smoothly in good to excellent yields and the pure products are separated from the reaction mixture by simple filtration.

Key words

multicomponent reaction - pyrimidine - dihydropyridine - barbituric acid - dimedone

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