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Synthesis 2011(7): 1132-1136
DOI: 10.1055/s-0030-1258463
DOI: 10.1055/s-0030-1258463
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient, One-Pot Synthesis of Pyrido[3,2-d]pyrimidine Derivatives
Further Information
Received
3 January 2011
Publication Date:
08 March 2011 (online)
Publication History
Publication Date:
08 March 2011 (online)
Abstract
A mild and efficient method for the synthesis of pyrido[3,2-d]pyrimidine derivatives via three-component domino reaction of amines, aldehydes, and terminal unactivated alkynes is described using BF3˙OEt2 as Lewis acid catalyst in one pot. The features of this procedure are mild reaction conditions, good to high yields, and shorter reaction time with operational simplicity.
Key words
multicomponent reaction - BF3˙OEt2 - pyrido[3,2-d]pyrimidine - aromatic aldehyde - phenylacetylene
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