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Synlett 2010(19): 2953-2955  
DOI: 10.1055/s-0030-1259025
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

2,2′,6-Tribromobiphenyl via Transition-Metal-Free ARYNE Coupling: A Valuable Tool in the Synthesis of Biphenyls

Laurence Bonnafoux, Françoise Colobert, Frédéric R. Leroux*
CNRS/Université de Strasbourg (ECPM), Laboratoire de Stéréochimie (UMR CNRS 7509), 67087 Strasbourg Cedex 2, France
Fax: +33(3)68852742; e-Mail: frederic.leroux@unistra.fr;
Further Information

Publication History

Received 27 August 2010
Publication Date:
03 November 2010 (online)

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Abstract

We report a high yielding synthesis of 2,2′,6-tribromobiphenyl (TBBP) via aryne coupling, and we discuss the fundamental influence of the reaction conditions.

Key words

arynes - biaryls - lithiation - metalation - cross-coupling

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