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Synthesis 2011(10): 1547-1554  
DOI: 10.1055/s-0030-1259983
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Copper(I) Iodide Catalyzed Synthesis of Quinolinones via Cascade Reactions of 2-Halobenzocarbonyls with 2-Arylacetamides

Liangbing Fua,b,1, Xiaoli Huanga,b,1, Deping Wanga,b, Pinghua Zhaoc, Ke Ding*a
a Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kai Yuan Road, Science Park, Guangzhou 510530, P. R. of China
Fax: +86(20)32015299; e-Mail: ding_ke@gibh.ac.cn;
b Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, No. 19 A Yuquan Road, Shijingshan District, Beijing 100049, P. R. of China
c GAC ChangFeng Motor Co. Ltd, YongZhou Branch, No. 68 Liebao North Road, Lengshuitan, Yongzhou, Hunan 425100, P. R. of China
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Publication History

Received 13 February 2011
Publication Date:
01 April 2011 (online)

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Abstract

An efficient copper-catalyzed method for the synthesis of quinolinones, pyridinones, and heteroannulated pyridinones via cascade reactions of substituted 2-iodo-, 2-bromo-, and 2-chlorobenzocarbonyls with 2-arylacetamides is reported. The protocol works well for the reaction of most of the 2-iodo-, 2-bromo- and 2-chlorobenzocarbonyls with 2-arylacetamides.

Key words

copper iodide - diamines - cascade reactions - amidation - quinolinones

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1

These two authors contributed equally to this work.