Triazinoquinazolinone derivatives are synthesized by cyclization
of aminobenzamide-substituted triazine compounds in the presence
of a proton source such as trifluoroacetic acid or hydrochloric
acid. The reaction is mild, general, and gives high yield (>90%)
of the cyclized product. This procedure allows, for the first time,
access to triazinoquinazolinone compounds bearing different functionalities
on the benzene and triazine moieties that are not available by other
routes.
amides - heterocycles - cyclization - carboxylic
acids - esters
