Synthesis of the Azepinoindole Framework via Oxidative Heck (Fujiwara-Moritani) Cyclization

Abstract

A catalytic oxidative Heck (Fujiwara-Moritani) cyclization has been evaluated for construction of the azepinoindole framework starting from readily available 3-indoleacetic acid amides. The supporting role of the amide group in the substrate has been demonstrated necessary for the success of the cyclization.

C-H activation - Heck reaction - palladium - indoles - heterocycles

References

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