Abstract
The use of palladium(0) enables a highly regioselective C-2 amination
of 4,6-dichloronicotinonitrile. Coupling with aminoarenes that are N-acetyl-masked to limit cross-coupling
overreaction, leads to 4-chloro-6-anilino nicotinonitrile compounds
after deprotection in situ. The scope of these original conditions
was evaluated.
Key words
regioselectivity - palladium - amination - pyridines - cross-coupling
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