Efficient Scaled-Up Synthesis of N-α-Fmoc-4-Phosphono(difluoromethyl)-l-phenylalanine and Its Incorporation into Peptides

Abstract

A rapid, robust and efficient scaled-up synthetic strategy for N-α-Fmoc-4-phosphono(difluoromethyl)-l-phenylalanine and its direct incorporation into peptides is presented herein.

Key words

phosphorylation - inhibitors - solid-phase synthesis - peptides - bioorganic chemistry

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