Abstract
Research in supramolecular chemistry has been carried out in
my laboratory for the past 12 years. Intrigued by the fascinating
power of supramolecular chemistry, as seen in biomolecular recognition
events in nature, we started out by trying to mimic the basic principles
of such recognition events in small artificial model systems. Our
first targets were amino acids and oligopeptides. We then moved
on to proteins and nucleic acids, and we started to develop supramolecular
systems that, besides simple binding, also featured functions, e.g.
shutting down enzymes or allowing gene delivery into cells. In recent
years and in a completely different yet related field, we have begun
to develop self-assembling nanomaterials. The basic idea for this
derived from an accidental discovery of the interesting self-assembling
properties of a simple zwitterion, which was a synthetic intermediate
on the route to our amino acid receptors. This personal account
summarizes this journey and is intended not only to present the
most-important findings from our laboratory so far, but also to
shed light on how all these projects developed over the years and
how our journey took us to where we are now.
1 Introduction
2 How It All Began
3 The Beginning: The Design of a New Oxoanion Binding Site
4 Tailor-Made Receptors for Small Peptides
5 Combinatorial Development of Peptide Receptors
6 From Small Peptides to Proteins
7 Nucleic Acids as Targets
8 Self-Assembling Zwitterions
9 pH-Switchable Nanostructures
10 Conclusion
Key words
supramolecular chemistry - molecular recognition - self-assembly - host-guest chemistry - combinatorial
chemistry
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