Association Study of Energy Homeostasis Genes and Antipsychotic-Induced Weight Gain in Patients with Schizophrenia

G. Jassim; J. Fernø; F. M. Theisen; M. Haberhausen; A. Christoforou; B. Håvik; S. Gebhardt; H. Remschmidt; C. Mehler-Wex; J. Hebebrand; S. LeHellard; V. M. Steen

doi:10.1055/s-0030-1263174

Pharmacopsychiatry 2011; 44(1): 15-20
DOI: 10.1055/s-0030-1263174

Original Paper

Association Study of Energy Homeostasis Genes and Antipsychotic-Induced Weight Gain in Patients with Schizophrenia

G. Jassim¹ ^, ² , J. Fernø¹ ^, ² , F. M. Theisen³ , M. Haberhausen³ , A. Christoforou¹ ^, ² , B. Håvik¹ ^, ² , S. Gebhardt⁴ , H. Remschmidt³ , C. Mehler-Wex⁶ , J. Hebebrand⁵ , S. LeHellard¹ ^, ² ^, ⁷ , V. M. Steen¹ ^, ² ^, ⁷

¹Department of Clinical Medicine, University of Bergen, Bergen, Norway
²Dr Einar Martens’ Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
³Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Marburg, Germany
⁴Department of Psychiatry and Psychotherapy, Philipps University, Marburg, Germany
⁵Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany
⁶Department of Child and Adolescent Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany
⁷These authors contributed equally

Abstract

Introduction: Marked inter-individual variation has been observed with respect to the risk of weight gain and related metabolic disturbances during antipsychotic treatment, which in part could be explained by heritability. Such adverse effects have been proposed to occur through drug-induced mechanisms involving both the central nervous system and different peripheral tissues.

Methods: We genotyped tagSNPs in several genes (ADIPOQ, PRKAA1, PRKAA2, PRKAB1, PRKAG1, PRKAG2, PRKAG3, FTO and FABP3) that regulate lipid and energy homeostasis for their possible association to antipsychotic-induced weight gain.

Results: In a sample of 160 patients of German origin with schizophrenia who had been monitored with respect to body weight, we found marked association between antipsychotic-related changes in BMI and 6 markers in the adiponectin gene (ADIPOQ).

Discussion: These findings support previous observations (in patients’ serum) that adiponectin is involved in antipsychotic-mediated metabolic adverse effects.

Full Text

References

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Correspondence

Prof. V. M. Steen

Center for Medical Genetics and

Molecular Medicine

Laboratory Building

Haukeland University Hospital

5021 Bergen

Norway

Phone: +47/55/975 475

Email: vidar.martin.steen@helse-bergen.no