PSYCH up2date, Table of Contents Psychiatrie und Psychotherapie up2date 2011; 5(3): 133-134DOI: 10.1055/s-0030-1266101 Editorial© Georg Thieme Verlag KG Stuttgart · New YorkFett polstert die NervenDie Rolle von Lipiden in der Ätiopathogenese neuropsychiatrischer KrankheitsbilderRecommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Full Text References Literatur 1 Kromhout D. Energy and macronutrient intake in lean and obese middle-aged men (the Zutphen study). Am J Clin Nutr. 1983; 37 295-299 2 Mukamal K J, Rimm E B, Kawachi I et al. Body mass index and risk of suicide among one million US adults. Epidemiology. 2010; 21 82-86 3 Pappolla M A, Bryant-Thomas T K, Herbert D et al. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology. 2003; 61 199-205 4 Féart C, Samieri C, Rondeau V et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. 2009; 302 638-648 5 Scarmeas N, Luchsinger J A, Schupf N et al. Physical activity, diet, and risk of Alzheimer disease. JAMA. 2009; 302 627-637 6 Ng T P, Gao Q, Niti M et al. Omega-3 polyunsaturated Fatty Acid supplements and cognitive decline: Singapore longitudinal aging studies. J Nutr Health Aging. 2011; 15 32-35 7 Morris M C, Evans D A, Bienias J L et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol. 2003; 60 940-946 8 Harold D, Abraham R, Hollingworth P et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat Genet. 2009; 41 1088-1093 9 Jones L, Holmans P A, Hamshere M L et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer’s disease. PLoS One. 2010; 5 e13950 10 Grimm M O, Grimm H S, Patzold A J et al. Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol. 2005; 7 1118-1123 11 Appleton K M, Rogers P J, Ness A R. Updated systematic review and meta-analysis of the effects of n-3 long-chain polyunsaturated fatty acids on depressed mood. Am J Clin Nutr. 2010; 91 757-770 12 Lafourcade M, Larrieu T, Mato S et al. Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci. 2011; 14 345-350 13 Darios F, Davletov B. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature. 2006; 440 813-817 14 Kornhuber J, Tripal P, Reichel M et al. Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. J Med Chem. 2008; 51 219-237 15 Kornhuber J, Reichel M, Tripal P et al. The role of ceramide in major depressive disorder. Eur Arch Psychiatry Clin Neurosci. 2009; 259 S199-S204 16 Kornhuber J, Tripal P, Reichel M et al. Functional inhibitors of acid sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem. 2010; 26 9-20 17 Fuchs B, Schiller J. MALDI-TOF MS analysis of lipids from cells, tissues and body fluids.. In: Quinn P J, Wang X, eds Lipids in Health and Disease.. Berlin: Springer Netherland; 2008: 541-565