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DOI: 10.1055/s-0030-1267183
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Comparison of HbA1c and OGTT Criteria to Diagnose Diabetes Among Chinese
Publication History
received 23.08.2010
first decision 23.08.2010
accepted 09.09.2010
Publication Date:
19 November 2010 (online)
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Abstract
Objective: To examine the sensitivity and specificity of HbA1c testing for the diagnosis of type 2 diabetes in high-risk adults in China and to compare the cardiaovascular risk factors between 2 groups of patients with glycemic status classified by the 2 different tests.
Research design and method: From a cross-sectional survey of prevalence of diabetes in China, we selected adults from the Jinan area of Shandong without known diabetes who underwent OGTT and HbA1c testing on the same day. Cardiovascular risk factors (blood pressure, body mass index, lipid levels) were compared among the subjects divided into 4 groups according to the 2 diabetes diagnostic criteria: true-diabetes, HbA1c-diagnosed diabetes, OGTT-diagnosed diabetes, and nondiabetes.
Results: Among 701 subjects, 65 cases of diabetes were diagnosed by HbA1c ≥6.5% and 94 cases by OGTT. Comparing with OGTT,the sensitivity with level of HbA1c >6.5% was 48.2% and the specificity 97.8%. In total, 30.7% of subjects with HbA1c ≥6.5% were not classified as having diabetes by OGTT criteria, and 52% of subjects with diabetes according to OGTT criteria would be considered nondiabetic by HbA1c recommended criteria. The OGTT- and HbA1c-diabetes groups showed the same cardiovascular risk factors, the levels of which were higher than that for the nondiabetes group.
Conclusions: We found high specificity and low sensitivity with use of HbA1c level ≥6.5% to diagnose diabetes mellitus. The HbA1c test and OGTT did not reach full concordance. The 2 diagnostic criteria reflect similar levels of cardiovascular risk factors.
Key words
HbA1c - type 2 diabetes - oral glucose tolerance test - cardiovascular risk factors
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Correspondence
L. Chen
Department of Endocrinology
Qilu Hospital
Shandong University
Cultural West Road 107
250012 Jinan City
Shandong
China
Phone: 86/130/06 596 179
Fax: 86/531/82 169 408
Email: dxljinan2007@163.com