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Planta Med 2011; 77(16): 1852-1854
DOI: 10.1055/s-0030-1271154
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

A New Cytotoxic β-Carboline Alkaloid from Galianthe thalictroides

Patrícia O. Figueiredo1 , Fernanda R. Garcez1 , Maria de Fátima C. Matos2 , Renata T. Perdomo2 , Lyara M. M. Queiroz2 , Arnildo Pott3 , Airton J. S. Garcez4 , Walmir S. Garcez1
  • 1Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
  • 2Departamento de Farmácia-Bioquímica, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
  • 3Departamento de Biologia, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
  • 4Agência de Desenvolvimento Agrário e Extensão Rural, Campo Grande, MS, Brazil
Further Information

Publication History

received December 16, 2010 revised April 1, 2011

accepted May 3, 2011

Publication Date:
01 June 2011 (online)

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Abstract

A cytotoxicity-guided fractionation of the roots of Galianthe thalictroides afforded a new β-carboline alkaloid, 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-β-carbolin-1-yl)cyclopentanol, which exhibited strong cytotoxic activity against three human cancer cell lines (MCF-7, 786-0, and UACC62). Its structure was established on the basis of 1D- and 2D-NMR spectroscopic techniques supported by HRMS data.

Key words

Galianthe thalictroides - Rubiaceae - β-carboline alkaloid - cytotoxic activity

Supporting Information

References

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Dr. Walmir Silva Garcez

CCET, Departamento de Química
Universidade Federal de Mato Grosso do Sul

Av. Senador Filinto Muller 1555

Campo Grande, MS 79074-460

Brazil

Phone: +55 67 33 45 35 79

Fax: +55 67 33 45 35 52

Email: walmir.garcez@ufms.br