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Planta Med 2011; 77(16): 1844-1847
DOI: 10.1055/s-0030-1271197
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Triterpenoids from Azadirachta indica

JinXiong Chen1 , 2 , JianChao Chen1 , Yun Sun1 , 2 , YuXin Yan1 , 2 , LingMei Kong1 , 2 , Yan Li1 , MingHua Qiu1
  • 1Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
  • 2Graduate School of the Chinese Academy of Sciences, Beijing, P. R. China
Further Information

Publication History

received April 11, 2011 revised May 13, 2011

accepted May 13, 2011

Publication Date:
14 June 2011 (online)

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Abstract

Two new tirucallane triterpenoids, 24,25-epoxy-3β-hydroxy-20-oxo-7-tirucallene (1) and 22,23;24,25-diepoxy-3β-hydroxy-7-tirucallene (2), and a new tetranortriterpenoid, 4α-hydroperoxy-6-O-acetylnimbandiol (3), along with eight known compounds, were isolated from the branches and leaves of Azadirachta indica. Their structures were elucidated through spectroscopic and chemical methods. The cytotoxic assay showed that the abundant constituent nimbolide (8) had obvious cytotoxic activities against HL-60, SMMC7721, A549, MCF-7, and SW-480 cell lines, with IC50 values of 0.8 ± 0.1, 2.2 ± 0.2, 1.9 ± 1.3, 4.5 ± 1.1, and 2.3 ± 0.1 µM, respectively.

Key words

Meliaceae - Azadirachta indica - tirucallane triterpenoid - tetranortriterpenoid - cytotoxicity

Supporting Information

References

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MingHua Qiu

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany, Chinese Academy of Sciences

132, LanHei Road

Kunming 650204, Yunnan

P. R. China

Phone: +86 871 5 22 33 27

Fax: +86 871 5 22 32 55

Email: mhchiu@mail.kib.ac.cn