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Dtsch Med Wochenschr 2011; 136(23): 1270-1274
DOI: 10.1055/s-0031-1272573
DOI: 10.1055/s-0031-1272573
Arzneimittel & Pharmakotherapie | Review article
Rheumatologie, Stoffwechselerkrankungen
© Georg Thieme Verlag KG Stuttgart · New York
Febuxostat
FebuxostatFurther Information
Publication History
eingereicht: 11.10.2010
akzeptiert: 31.3.2011
Publication Date:
23 May 2011 (online)
Schlüsselwörter
Gicht - Febuxostat - Harnsäure - Urikostatikum - Xanthinoxidase-Inhibitor
Keywords
gout - febuxostat - uric acid - uricostatic drug - xanthine-oxidase-inhibitor
Literatur
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- 2 Becker M A, Schumacher H R, Espinoza L R. et al . The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. Arthritis Res Ther. 2010; 12 R63
- 3 Becker M A, Schumacher Jr H R, Wortmann R L. et al . Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med. 2005; 353 2450-2461
- 4 Becker M A, Schumacher Jr H R, Wortmann R L. et al . Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout. Arthritis Rheum. 2005; 52 916-923
- 5 Becker M A, Schumacher H R, MacDonald P A. et al . Clinical efficacy and safety of successful longterm urate lowering with febuxostat or allopurinol in subjects with gout. J Rheumatol. 2009; 36 1273-1282
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- 11 Lee H Y, Ariyasinghe J T, Thirumoorthy T. Allopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?. Singapore Med J. 2008; 49 384-387
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- 16 Okamoto K, Nishino T. Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors: allopurinol, febuxostat, and FYX-051. J Nippon Med Sch. 2008; 75 2-3
- 17 Reinders M K, Haagsma C, Jansen T L. et al . A randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300 – 600 mg/day versus benzbromarone 100 – 200 mg/day in patients with gout. Ann Rheum Dis. 2009; 68 892-897
- 18 Schumacher Jr H R. Febuxostat: a non-purine, selective inhibitor of xanthine oxidase for the management of hyperuricaemia in patients with gout. Expert Opin Investig Drugs. 2005; 14 893-903
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Prof. Dr. med. Ali El-Armouche
Abteilung Pharmakologie
Universitätsmedizin
Göttingen
Robert-Koch-Str. 40
37075
Göttingen
Phone: 0551/39-22602
Fax: 0551/39-5699
Email: ali.el-armouche@med.uni-goettingen.de