ABSTRACT
The possible correlation between the mean platelet volume (MPV) and the occurrence
of bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH) in a cohort
of preterm infants was assessed. We studied infants with gestational age <30 weeks.
Enrolled infants were divided into BPD and no-BPD groups and IVH and no-IVH groups.
MPV was evaluated at birth and at 24 to 48 hours of life. MPV measured at birth was
similar in BPD and no-BPD groups, but at 24 to 48 hours of life was higher in the
BPD than in the no-BPD group (11.1 ± 0.9 versus 10.8 ± 0.9 fL, p = 0.033) and multivariate analysis demonstrated that MPV >11 fL increases (relative
risk 1.40, 95% confidence interval 1.08 to 1.80) the risk of developing BPD. MPV was
similar in infants with or without IVH. We concluded that high MPV in the first days
of life is a risk factor for the development of BPD in extremely preterm infants.
This might be because high MPV could favor inflammatory and oxidative lung damage.
On the contrary, our data indicate that MPV is not associated with the development
of IVH in our population.
KEYWORDS
Platelet volume - bronchopulmonary dysplasia - intraventricular hemorrhage - preterm
infant
REFERENCES
- 1
Vizioli L, Muscari S, Muscari A.
The relationship of mean platelet volume with the risk and prognosis of cardiovascular
diseases.
Int J Clin Pract.
2009;
63
1509-1515
- 2
Cesari F, Marcucci R, Caporale R et al..
Relationship between high platelet turnover and platelet function in high-risk patients
with coronary artery disease on dual antiplatelet therapy.
Thromb Haemost.
2008;
99
930-935
- 3
Chu S G, Becker R C, Berger P B et al..
Mean platelet volume as a predictor of cardiovascular risk: a systematic review and
meta-analysis.
J Thromb Haemost.
2010;
8
148-156
- 4
Arad I D, Alpan G, Sznajderman S D, Eldor A.
The mean platelet volume (MPV) in the neonatal period.
Am J Perinatol.
1986;
3
1-3
- 5
Wasiluk A, Osada J, Dabrowska M, Szczepański M, Jasinska E.
Does prematurity affect platelet indices?.
Adv Med Sci.
2009;
54
253-255
- 6
Patrick C H, Lazarchick J, Stubbs T, Pittard W B.
Mean platelet volume and platelet distribution width in the neonate.
Am J Pediatr Hematol Oncol.
1987;
9
130-132
- 7
Gioia S, Piazze J, Anceschi M M et al..
Mean platelet volume: association with adverse neonatal outcome.
Platelets.
2007;
18
284-288
- 8
Canpolat F E, Yurdakök M, Armangil D, Yiğit S.
Mean platelet volume in neonatal respiratory distress syndrome.
Pediatr Int.
2009;
51
314-316
- 9
Yurdakök M, Oran O, Dündar S, Tekinalp G, Kirazli S.
Reduced fibrinolytic state in early respiratory distress syndrome.
Am J Hematol.
1993;
42
233-234
- 10
Yurdakök M, Yiğit S.
Hemostatic system in early respiratory distress syndrome: reduced fibrinolytic state?.
Turk J Pediatr.
1999;
41
489-493
- 11
Setzer E S, Webb I B, Wassenaar J W, Reeder J D, Mehta P S, Eitzman D V.
Platelet dysfunction and coagulopathy in intraventricular hemorrhage in the premature
infant.
J Pediatr.
1982;
100
599-605
- 12
Andrew M, Castle V, Saigal S, Carter C, Kelton J G.
Clinical impact of neonatal thrombocytopenia.
J Pediatr.
1987;
110
457-464
- 13
Rennie J M, Doyle J, Cooke R W.
Elevated levels of immunoreactive prostacyclin metabolite in babies who develop intraventricular
haemorrhage.
Acta Paediatr Scand.
1987;
76
19-23
- 14
Counsell S J, Maalouf E F, Rutherford M A, Edwards A D.
Periventricular haemorrhagic infarct in a preterm neonate.
Eur J Paediatr Neurol.
1999;
3
25-27
- 15
Takashima S, Mito T, Ando Y.
Pathogenesis of periventricular white matter hemorrhages in preterm infants.
Brain Dev.
1986;
8
25-30
- 16
Ehrenkranz R A, Walsh M C, Vohr B R National Institutes of Child Health and Human
Development Neonatal Research Network et al.
Validation of the National Institutes of Health consensus definition of bronchopulmonary
dysplasia.
Pediatrics.
2005;
116
1353-1360
- 17
Papile L A, Burstein J, Burstein R, Koffler H.
Incidence and evolution of subependymal and intraventricular hemorrhage: a study of
infants with birth weights less than 1,500 gm.
J Pediatr.
1978;
92
529-534
- 18
Merritt T A, Deming D D, Boynton B R.
The “new” bronchopulmonary dysplasia: challenges and commentary.
Semin Fetal Neonatal Med.
2009;
14
345-357
- 19
Vizioli L, Muscari S, Muscari A.
The relationship of mean platelet volume with the risk and prognosis of cardiovascular
diseases.
Int J Clin Pract.
2009;
63
1509-1515
- 20
Haagsman H P.
Oxidative damage of the pulmonary surfactant system.
Semin Neonatol.
1998;
3
207-217
- 21
Nogee L M, Wispé J R, Clark J C, Weaver T E, Whitsett J A.
Increased expression of pulmonary surfactant proteins in oxygen-exposed rats.
Am J Respir Cell Mol Biol.
1991;
4
102-107
- 22
Horowitz S, Shapiro D L, Finkelstein J N, Notter R H, Johnston C J, Quible D J.
Changes in gene expression in hyperoxia-induced neonatal lung injury.
Am J Physiol.
1990;
258
(2 Pt 1)
L107-L111
- 23
Schock B C, Sweet D G, Ennis M, Warner J A, Young I S, Halliday H L.
Oxidative stress and increased type-IV collagenase levels in bronchoalveolar lavage
fluid from newborn babies.
Pediatr Res.
2001;
50
29-33
- 24
Kuter D J, Rosenberg R D.
The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet
mass during busulfan-induced thrombocytopenia in the rabbit.
Blood.
1995;
85
2720-2730
- 25
Bassan H.
Intracranial hemorrhage in the preterm infant: understanding it, preventing it.
Clin Perinatol.
2009;
36
737-762
Carlo DaniM.D.
Division of Neonatology, Careggi University Hospital, University of Florence School
of Medicine, Viale Morgagni
85 Firenze, Italy
eMail: cdani@unifi.it
