RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000011.xml
Dtsch Med Wochenschr 2011; 136(11): 548-550
DOI: 10.1055/s-0031-1274540
DOI: 10.1055/s-0031-1274540
Kommentar | Commentary
Endokrinologie
© Georg Thieme Verlag KG Stuttgart · New York
Energie, braunes Fettgewebe und Adipositas
Energy, brown adipose tissue, obesityWeitere Informationen
Publikationsverlauf
eingereicht: 19.12.2010
akzeptiert: 3.3.2011
Publikationsdatum:
08. März 2011 (online)

Schlüsselwörter
braunes Fettgewebe - BAT - Adipositas - Diabetes - Fettstoffwechselstörung
Keywords
brown adipose tissue - BAT - obesity - diabetes - lipid disorder
Literatur
- 1 Agarwal A K, Garg A. Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways. Trends Endocrinol Metab. 2003; 14 214-221
- 2 Balkau B, Deanfield J E, Despres J P. et al . International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries. Circulation. 2007; 116 1942-1951
- 3 Bartelt A, Bruns O T, Reimer R. et al . Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011; 17 200-205
- 4 Cypess A M, Lehman S, Williams G. et al . Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009; 360 1509-1517
- 5 Elmquist J K. Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Physiol Behav. 2001; 74 703-708
- 6 Frontini A, Cinti S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab. 2010; 11 253-256
- 7 Hamann A, Flier J S, Lowell B B. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology. 1996; 137 21-29
- 8 Hany T F, Gharehpapagh E, Kamel E M, Buck A, Himms-Hagen J, von Schulthess G K. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging. 2002; 29 1393-1398
- 9 Hummasti S, Hotamisligil G S. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res. 2010; 107 579-591
- 10 International Diabetes Foundation (IDF) .Diabetes-Atlas. 2010 http://www.diabetesatlas.org/
- 11 Kajimura S, Seale P, Kubota K. et al . Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009; 460 1154-1158
- 12 Kajimura S, Seale P, Spiegelman B M. Transcriptional control of brown fat development. Cell Metab. 2010; 11 257-262
- 13 Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak L P. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest. 1995; 96 2914-2923
- 14 Lean M E. Brown adipose tissue in humans. Proc Nutr Soc. 1989; 48 243-256
- 15 Lee P, Greenfield J R, Ho K K, Fulham M J. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2010; 299 E601-606
- 16 Lowell B B, V S S, Hamann A. et al . Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993; 366 740-742
- 17 Muller-Wieland D, Knebel B, Haas J, Merkel M, Kotzka J. Adipositas: ektope Fettverteilung und Herz. Herz. 2010; 35 198-205
- 18 Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2007; 293 E444-452
- 19 Oral E A, Simha V, Ruiz E. et al . Leptin-replacement therapy for lipodystrophy. N Engl J Med. 2002; 346 570-578
- 20 Unger R H, Clark G O, Scherer P E, Orci L. Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim Biophys Acta. 2010; 1801 209-214
- 21 van Marken L ichtenbelt WD, Vanhommerig J W, Smulders N M. et al . Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009; 360 1500-1508
- 22 Virtanen K A, Lidell M E, Orava J. et al . Functional brown adipose tissue in healthy adults. N Engl J Med. 2009; 360 1518-1525
PD Dr. med. Martin Merkel
Oberarzt
Asklepios Klinik St. Georg
1.
Medizinische Abteilung
(Diabetes, Stoffwechsel, Endokrinologie,
Gastroenterologie und Allgemeine Innere Medizin)
Lohmühlenstr.
5
20099 Hamburg
Telefon: 040/18
18-85 2352
Fax: 040/18 18-85 2323
eMail: m.merkel@asklepios.com