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DOI: 10.1055/s-0031-1280264
© Georg Thieme Verlag KG Stuttgart · New York
Antifungal Sesquiterpenes from Cedrus deodara
Publication History
received May 30, 2011
revised September 5, 2011
accepted September 7, 2011
Publication Date:
06 October 2011 (online)
![](https://www.thieme-connect.de/media/plantamedica/201202/lookinside/thumbnails/10.1055-s-0031-1280264-1.jpg)
Abstract
Two new sesquiterpenes, (E)-(2S,3S,6R)-atlantone-2,3-diol (1) and (E)-(2S,3S,6S)-atlantone-2,3,6-triol (2), along with two known sesquiterpenes, atlantolone (3) and (E)-α-atlantone (4), were isolated from Cedrus deodara Loud. The structures of the new compounds were elucidated on the basis of UV, IR, NMR, HR-ESI-QTOF-MS, and EI mass spectral studies. The n-hexane and chloroform extracts of sawdust and compounds 3 and 4 from the plant exhibited antifungal activity against Aspergillus flavus, A. niger, A. ochracoeus, A. parasiticus, and A. sydowii. A weak activity was also recorded against A. parasiticus and A. sydowii for compound 1, while Trichophyton rubrum was inhibited by compound 2 and the extracts.
Key words
Cedrus deodara - Pinaceae - sesquiterpenes - atlantone - antifungal activity
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Dr. Bikram Singh
Natural Plant Products Division
CSIR-Institute of Himalayan Bioresource Technology
IHBT Communication No. 2104
Palampur, H. P., 176 061
India
Phone: +91 18 94 23 04 26
Fax: +91 1894 23 04 33
Email: bikramsingh@ihbt.res.in