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DOI: 10.1055/s-0031-1280265
© Georg Thieme Verlag KG Stuttgart · New York
Constituents with DNA Topoisomerases I and II Inhibitory Activity and Cytotoxicity from the Roots of Rubia cordifolia
Publication History
received March 11, 2010
revised June 13, 2011
accepted August 30, 2011
Publication Date:
06 October 2011 (online)
![](https://www.thieme-connect.de/media/plantamedica/201202/lookinside/thumbnails/10.1055-s-0031-1280265-1.jpg)
Abstract
Activity-directed isolation of the ethyl acetate fraction from the roots of Rubia cordifolia resulted in the identification of a new anthraquinone, 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-(6′-O-acetyl)-glucopyranoside (1), two new dihydronaphtoquinones, 1,4-dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside (2) and mollugin-1-O-β-D-glucopyranoside (3), and a new monoterpenoid, 3R,3aS,4R,6aR-3,4,6-tris(hydroxymethyl)-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one (4), together with nine known compounds (5–13). The structures of these compounds were elucidated on the basis of spectroscopic evidence. In addition, their DNA topoisomerases I and II inhibitory activity and cytotoxicity were measured.
Key words
Rubia cordifolia - Rubiaceae - DNA topoisomerases I and II inhibitory activity - cytotoxicity
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Prof. Dr. Mi-Hee Woo
College of Pharmacy
Catholic University of Daegu
330 Geumnak 1-ri, Hayang-eup
Gyeongsan-si
Gyeongbuk 712-702
Rep. of Korea
Phone: +82 5 38 50 36 20
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Email: woomh@cu.ac.kr