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DOI: 10.1055/s-0031-1280347
© Georg Thieme Verlag KG Stuttgart · New York
Metabolites of the Mangrove Fungus Xylaria sp. BL321 from the South China Sea
Publication History
received August 24, 2010
revised September 20, 2011
accepted October 14, 2011
Publication Date:
14 November 2011 (online)
![](https://www.thieme-connect.de/media/plantamedica/201202/lookinside/thumbnails/10.1055-s-0031-1280347-1.jpg)
Abstract
Two new lactones, 1 and 2, together with five known compounds, 3–7, were isolated from the marine mangrove fungus Xylaria sp. BL321. Their structures were determined by comprehensive analysis of their MS and NMR spectroscopic data. The absolute configurations of 1 and 2 were established on the basis of electronic circular dichroism calculations. It was found that the exocyclic double bond of 1 rearranged into a cyclic double bond to form a new crystal compound (1a) in diluted NaOH solution. Compound 3 was isolated for the first time as a natural product; its absolute configuration was determined by single-crystal X-ray crystallography. Compounds 4–7 displayed cytotoxicity against human breast cancer cell lines MCF-7 and MDA-MB-435, while compounds 1–3 were inactive (IC50 > 50 µM).
Key words
Xylaria sp. - Acanthus ilicifolius L. - Acanthaceae - mangrove fungus - lactone - electronic circular dichroism
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Prof. Dr. Lan Liu
Prof. Dr. Yong-Cheng Lin
School of Chemistry and Chemical Engineering
Sun Yat-sen University
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P. R. China
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