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Int J Sports Med 2012; 33(01): 76-80
DOI: 10.1055/s-0031-1285866
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

MtDNA Haplogroups and Elite Korean Athlete Status

K. C. Kim
1   Biological Sciences, Dankook University, Cheonan, Republic of Korea
,
H. I. Cho
2   Sports Management, Dankook University, Cheonan, Republic of Korea
,
W. Kim
1   Biological Sciences, Dankook University, Cheonan, Republic of Korea
› Author Affiliations
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Publication History



accepted after revision 14 July 2011

Publication Date:
01 December 2011 (online)

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Abstract

Mitochondrial DNA (mtDNA) variation has recently been suggested to have an association with athletic performance or physical endurance. Since mtDNA is haploid and lacks recombination, specific mutations in the mtDNA genome associated with human exercise tolerance or intolerance arise and remain in particular genetic backgrounds referred to as haplogroups. To assess the possible contribution of mtDNA haplogroup-specific variants to differences in elite athletic performance, we performed a population-based study of 152 Korean elite athletes [77 sprint/power athletes (SPA) and 75 endurance/middle-power athletes (EMA)] and 265 non-athletic controls (CON). The overall haplogroup distribution of EMA differed significantly from CON (p<0.01), but that of SPA did not. The EMA have an excess of haplogroups M* (OR 4.38, 95% CI 1.63–11.79, p=0.003) and N9 (OR 2.32, 95% CI 0.92–5.81, p=0.042), but a dearth of haplogroup B (OR 0.26, 95% CI 0.09–0.75, p=0.003) compared with the CON. Thus, our data imply that specific mtDNA lineages may provide a significant effect on elite Korean endurance status, although functional studies with larger sample sizes are necessary to further substantiate these findings.

Key words

mitochondrial DNA - mtDNA haplogroup - physical endurance - association study
 

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