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Zeitschrift für Phytotherapie 2012; 33(1): 19-23
DOI: 10.1055/s-0031-1286040
Forschung
Urolithiasis
© Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Efficacy of a fixed combination of Centaurii herba, Levistici radix and Rosmarini folium in urinary lithiasis

Results of an open randomised cohort study
Emil Ceban
Subject Editor:
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Publication History

Publication Date:
22 March 2012 (online)

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Zusammenfassung

Wirksamkeit eines Kombinationsarzneimittels aus Centaurii herba, Levistici radix und Rosmarini folium bei Urolithiasis: Ergebnisse einer offenen, randomisierten, Kohortenstudie

Urolithiasis (Harnsteinleiden; Bildung von Konkrementen in den ableitenden Harnwegen) kann zu schmerzhaften, kolikartigen Schmerzen führen, wenn die Konkremente oder Steine die Harnwege blockieren. Pflanzliche Drogenzubereitungen spielen seit Langem eine bedeutsame Rolle in der Prophylaxe und Therapie des Harnsteinleidens. In einigen Studien wurde bereits die Wirkung des Phytopharmakons Canephron® N, einer fixen Kombination der Drogen Centaurii herba, Levistici radix und Rosmarini folium, bei der Urolithiasis gezeigt. In einer aktuellen offenen, randomisierten, monozentrischen Kohortenstudie wurde die Therapie mit Canephron® N als Add-on-Therapie untersucht. Das Phytopharmakon wurde 135 Patienten zusätzlich zur Standardtherapie verabreicht, die Daten dieser Kohorte wurden mit den Daten von 102 Patienten unter Standardtherapie verglichen. Canephron® N begünstigte die spontane Elimination von Konkrementen und verminderte die Leukozyturie, die insbesondere mit entzündlichen Prozessen im Harntrakt einhergeht. Die Anwendung der Kombination zur Prävention und/oder als Add-on-Therapie in Ergänzung der Standardtherapie der Urolithiasis erscheint gerechtfertigt.

Summary

Urolithiasis describes the formation of calculi in kidney and efferent urinary passages. If these calculi jam urinary passages, it is often associated with typical spastic pain attacks. Certain herbal drugs play a special role in urolithiasis prophylaxis and treatment. The herbal medical product Canephron® N, a combination of Centaurii herba, Levistici radix and Rosmarini folium, is established in the therapy of urolithiasis, the indication is proven by some clinical studies. In a randomised open monocentric add-on cohort study, the efficacy of Canephron® N was investigated for the treatment of urolithiasis. The herbal medical product was administered in 135 patients additionally to standard therapy, for comparison 102 patients were treated with standard therapy only. Canephron® N favours the spontaneous elimination of small calculi and significantly decreases leucocyturia, especially associated with urinary infection. Therefore it is justified to suggest the combination for prevention and/or in addition to standard therapy of urolithiasis.

Key words

Urolithiasis - herbal therapy - Centaurium spp. - Levisticum officinale - Rosmarinus officinalis - open randomised cohort study - efficacy

Schlüsselwörter

Urolithiasis - Phytotherapie - Centaurium spp. - Levisticum officinale - Rosmarinus officinalis - offene randomisierte Kohortenstudie - Wirksamkeit
 

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