DMW – Klinischer Fortschritt, Table of Contents Dtsch Med Wochenschr 2011; 136(40): 2007-2010DOI: 10.1055/s-0031-1286381 Hämatologie & Onkologie | Commentary Hämatologie © Georg Thieme Verlag KG Stuttgart · New York Chronische myeloische Leukämie Chronic myeloid leukemiaA. Hochhaus1 1Abteilung Hämatologie und internistische Onkologie und UniversitätsTumorCentrum am Universitätsklinikum Jena Recommend Article Abstract Buy Article Schlüsselwörter chronische myeloische Leukämie - Tyrosinkinase-Inhibitoren - Interferon alpha - allogene Stammzelltransplantation - minimale Resterkrankung Keywords chronic myeloid leukemia - tyrosine kinase inhibitors - interferon alpha - allogenic stem cell transplantation - minimal residual disease Full Text References Literatur 1 Baccarani M, Cortes J, Pane F. et al . Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol. 2009; 27 6041-6051 2 Burchert A, Müller M C, Kostrewa P. et al . Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia. J Clin Oncol. 2010; 28 1429-1435 3 Cortes J E, Baccarani M, Guilhot F. et al . Phase III, randomized, open-label study of daily imatinib mesylate 400 mg versus 800 mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: tyrosine kinase inhibitor optimization and selectivity study. J Clin Oncol. 2010; 28 424-430 4 Cortes J, Hochhaus A, Hughes T, Kantarjian H. Front-line and salvage therapies with tyrosine kinase inhibitors and other treatments in chronic myeloid leukemia. J Clin Oncol. 2011; 29 524-531 5 Hasford J, Baccarani M, Hoffmann V. et al . Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood. 2011; 118 686-692 6 Hehlmann R, Lauseker M, Jung-Munkwitz S. et al . Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-a in newly diagnosed chronic myeloid leukemia. J Clin Oncol. 2011; 29 1634-1642 7 Hochhaus A, La Rosée P, Müller M C, Ernst T, Cross N C. Impact of BCR-ABL mutations on patients with chronic myeloid leukemia. Cell Cycle. 2011; 10 250-260 8 Hughes T P, Hochhaus A, Branford S. et al . Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood. 2010; 116 3758-3765 9 Kantarjian H, Shah N P, Hochhaus A. et al . Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2010; 362 2260-2270 10 Mahon F X, Réa D, Guilhot J. et al . Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010; 11 1029-1035 11 Marin D, Bazeos A, Mahon F X. et al . Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol. 2010; 28 2381-2388 12 Müller M C, Cross N C, Erben P. et al . Harmonization of molecular monitoring of CML therapy in Europe. Leukemia. 2009; 23 1957-1963 13 Preudhomme C, Guilhot J, Nicolini F E. et al . Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med. 2010; 363 2511-2521 14 Saglio G, Kim D W, Issaragrisil S. et al . Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med. 2010; 362 2251-2259 15 Simonsson B, Gedde-Dahl T, Markevärn B. et al . Combination of pegylated interferon-a2b with imatinib increases molecular response rates in patients with low or intermediate risk chronic myeloid leukemia. Blood. 2011 Jun 17 ; [Epub ahead of print] Prof. Dr. Andreas Hochhaus Universitätsklinikum JenaKlinik für Innere Medizin II, Abteilung Hämatologie und internistische Onkologie Erlanger Allee 101 07740 Jena Phone: 03641/932 4201 Fax: 03641/932 4202 Email: andreas.hochhaus@med.uni-jena.de