The Continuous-Flow Synthesis
of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling
Reaction

Samuel L. Bourne; Peter Koos; Matthew O’Brien; Benjamin Martin; Berthold Schenkel; Ian R. Baxendale; Steven V. Ley

doi:10.1055/s-0031-1289291

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Synlett 2011(18): 2643-2647
DOI: 10.1055/s-0031-1289291

LETTER

The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction

Samuel L. Bourne^a, Peter Koos^a, Matthew O’Brien^a, Benjamin Martin^b, Berthold Schenkel^b, Ian R. Baxendale^a, Steven V. Ley*^a
^a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
e-Mail: svl1000@cam.ac.uk;
^b Chemical & Analytical Development, Novartis Pharma AG, Werk Klybeck, Klybeckstr. 141, 4057 Basel, Switzerland

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Publikationsverlauf

Received 19 August 2011
Publikationsdatum:
07. Oktober 2011 (online)

Abstract
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Abstract

We report a palladium-catalysed ethylene Heck reaction for the vinylation of aryl iodides using a tube-in-tube gas-liquid reactor. The flow process afforded various styrenes in short reaction times, employing moderate ethylene pressure.

Key words

vinylation - membrane - flow - ethylene - styrene

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