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Synlett 2011(18): 2643-2647  
DOI: 10.1055/s-0031-1289291
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction

Samuel L. Bournea, Peter Koosa, Matthew O’Briena, Benjamin Martinb, Berthold Schenkelb, Ian R. Baxendalea, Steven V. Ley*a
a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
e-Mail: svl1000@cam.ac.uk;
b Chemical & Analytical Development, Novartis Pharma AG, Werk Klybeck, Klybeckstr. 141, 4057 Basel, Switzerland
Further Information

Publication History

Received 19 August 2011
Publication Date:
07 October 2011 (online)

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Abstract

We report a palladium-catalysed ethylene Heck reaction for the vinylation of aryl iodides using a tube-in-tube gas-liquid reactor. The flow process afforded various styrenes in short reaction times, employing moderate ethylene pressure.

Key words

vinylation - membrane - flow - ethylene - styrene

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