Supported Synthesis of Halogenated
Organic Compounds

Sophie Boldon; Ida S. R. Stenhagen; Jane E. Moore; Sajinder K. Luthra; Véronique Gouverneur

doi:10.1055/s-0031-1289590

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Synthesis 2011(24): 3929-3953
DOI: 10.1055/s-0031-1289590

REVIEW

Supported Synthesis of Halogenated Organic Compounds

Sophie Boldon^a, Ida S. R. Stenhagen^a, Jane E. Moore^b, Sajinder K. Luthra^c, Véronique Gouverneur*^a
^a Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK
Fax: +44(1865)275644; e-Mail: veronique.gouverneur@chem.ox.ac.uk;
^b AstraZeneca UK, Alderley Park, Cheshire, SK10 4TG, UK
^c GE Healthcare, The Grove Centre, White Lion Road, Amersham, HP7 9LL, UK

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Publikationsverlauf

Received 23 August 2011
Publikationsdatum:
08. November 2011 (online)

Abstract
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Abstract

Halogenated organic compounds are highly sought after in a wide variety of fields, for example synthetic and medicinal chemistry as well as materials science. The supported synthesis of organohalogens has been extensively developed in the field of imaging where rapid purification of radiotracers containing isotopes with short half-lives is of great importance. Electrophilic and nucleophilic halogenation occurs upon cleavage from the support and the desired labeled product is readily separated from contaminants. This review provides a discussion as to how supported synthetic routes have facilitated the preparation of halogenated compounds.

1 Introduction

2 Halogenation of Supported Precursors

2.1 Fluorination

2.2 Chlorination

2.3 Bromination

2.4 Iodination

3 Conclusion

Key words

halogenation - solid support - fluorous - radiochemistry - detagging

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