Synthesis of Quinolines via
Friedländer Reaction in Water and under Catalyst-Free
Conditions

Qiang Shen; Limin Wang; Jianjun Yu; Mingtao Liu; Jun Qiu; Lei Fang; Fenglou Guo; Jun Tang

doi:10.1055/s-0031-1289657

PAPER

Synthesis of Quinolines via Friedländer Reaction in Water and under Catalyst-Free Conditions

Qiang Shen, Limin Wang*, Jianjun Yu, Mingtao Liu, Jun Qiu, Lei Fang, Fenglou Guo, Jun Tang
Shanghai Key Laboratory of Functional Materials Chemistry, and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China
Fax: +86(21)64253881; e-Mail: wanglimin@ecust.edu.cn;

Abstract

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Abstract

A straightforward and efficient method for the synthesis of quinolines via Friedländer reaction of 2-aminobenzaldehyde with various ketones or malononitrile in water without using any catalyst at 70 ˚C is reported.

Key words

catalyst-free - water - Friedländer reaction - ketones - quinolines

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